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中藥標(biāo)準(zhǔn)品
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產(chǎn)品編號(hào) |
英文名稱 |
CAS號(hào) |
包裝 |
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Y3696 |
Baicalein |
491-67-8 |
可根據(jù)客戶要求訂制 |
產(chǎn)品編號(hào)：Y3696
英文名稱：Baicalein
CAS號(hào)：491-67-8分析標(biāo)準(zhǔn)品,≥98%
分子式 C15H10O5 分子量270.24
基本信息:
敏感性 對(duì)光和熱敏感
密度 1.548
熔點(diǎn) 256-271°C
溶解性 Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water
存貯條件 儲(chǔ)存溫度2-8℃
描述
產(chǎn)品介紹 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.
別名 三羥黃酮; 黃芩苷元; 黃芩黃素; 黃芩甙元; 5,6,7-三羥基黃酮;5,6,7-Trihydroxyflavone
生化機(jī)理 中藥類黃酮的組成成分，黃芩的主要黃酮，抑制花生四烯酸代謝中的12-脂肪氧化酶路徑（12-lipoxygenase ，12-LOX），此路徑能抑制癌細(xì)胞的增殖，誘導(dǎo)凋亡途徑。
應(yīng)用 An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
