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標(biāo)記一抗
英文名稱Anti-ANKRD13A/FITC
中文名稱:FITC標(biāo)記的錨蛋白重復(fù)結(jié)構(gòu)域蛋白13A抗體
別 名ANKRD13; ANKRD13A ankyrin repeat domain 13A; ANKRD13A; Ankyrin repeat domain 13; Protein KE03; AN13A_HUMAN.
規(guī)格:100ul
說 明 書100ul
研究領(lǐng)域細(xì)胞生物 免疫學(xué)
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ANKRD13A
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane
Subunit:
Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.
Subcellular Location:
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Post-translational modifications:
Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.
Similarity:
Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats.
中文名稱:FITC標(biāo)記的錨蛋白重復(fù)結(jié)構(gòu)域蛋白13A抗體
別 名ANKRD13; ANKRD13A ankyrin repeat domain 13A; ANKRD13A; Ankyrin repeat domain 13; Protein KE03; AN13A_HUMAN.
詳細(xì)介紹：
規(guī)格:100ul
說 明 書100ul
研究領(lǐng)域細(xì)胞生物 免疫學(xué)
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Cow, Rabbit, Sheep,
產(chǎn)品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ANKRD13A
亞 型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料：
產(chǎn)品介紹Function:
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane
Subunit:
Interacts (via the UIM 3 and 4 repeats) with EGFRc(ubiquitinated); the interaction is direct, inhibited by ANKRD13A monoubiquitination and may regulate EGFR internalization.
Subcellular Location:
Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
Post-translational modifications:
Monoubiquitinated, inhibits interaction with ubiquitinated EGFR.
Similarity:
Contains 2 ANK repeats.
Contains 3 UIM (ubiquitin-interacting motif) repeats.
