產(chǎn)品編號：Y0702

英文名稱：Chenodeoxycholic acid

CAS號 474-25-9

分析標準品

分子式 C24H40O4 分子量392.58

基本信息:

敏感性對光敏感

密度1.128

存貯條件密封避光保存。

描述

產(chǎn)品介紹味苦、有異臭。易溶于乙醇、甲醇、丙酮和乙酸，幾乎不溶于水、石油醚和苯。

別名鵝去氧膽酸 ;脫氧鵝膽酸；鵝脫氧膽酸；3α,7α-二羥基膽質(zhì)酸；3α,7α-二羥基-5-β-膽烷酸;

生化機理

Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. EC50 concentrations for activation of FXR range from 13-34 μM. In cells, Chenodeoxycholic Acid also binds to bile acid binding proteins (BABP) with a reported stiochiometery of 1:2. Chenodeoxycholic Acid toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess Chenodeoxycholic Acid contributes to liver and intestinal cancers.

應(yīng)用主要用于合成熊去氧膽酸。

膽石溶解劑，用于膽固醇高而引起的結(jié)石、膽道炎和膽囊炎等。